Jan van Eyck's Arnolfini Portrait is already the National Gallery's most popular painting online and the London institution is hoping it will have real-life appeal at the heart of a major new show.
It is one of more than 20 paintings by the 15th-century Dutch painter going on show next year in the first ever exhibition of his portraits.
The 1434 painting, which is part of the gallery's collection and is the subject of the most visited painting page on its website, will be shown alongside another portrait of the same sitter on loan from Berlin's Gemaldegalerie.
The gallery said in the last three years it had 396,046 page views - almost 150,000 more than the next most popular which was its Van Gogh's Sunflowers.
Also in the show is van Eyck's portrait of his wife, Margaret, which is one of the earliest known secular portraits of a woman who was not a member of the aristocracy.
Van Eyck: The Portraits opens on November 21 next year and will run to April 11, 2027.