Having helped power the recent success of the New York sales, it is fitting Frida Kahlo is one of the stars of the show at Art Basel Miami Beach.
Her miniature self-portrait, for sale for $15 million from the Weinstein Gallery, drew large crowds to its booth at the art fair and was still on offer at the end of the day.
It comes after another self-portrait, El sueno (La cama), sold for $54.66 million in Sotheby's surrealist sale last month.
Also drawing the crowds were a series of robotic dogs - complete with the heads of tech bros Mark Zuckerberg and Jeff Bezos as well as Pablo Picasso and Andy Warhol - by digital artist Beeple which were on show at the fair's new digital-art section Zero 10.
Described by one visitor as "the creepiest thing I've ever seen at a fair", their unsettling nature did not put off buyers with all 20 going for $100,000 each.
Beeple's showstopper and brisk sales across the floor all added up to a positive atmosphere on the first day.
Other reported early sales include a Gerhard Richter abstract which went for $5.5 million from David Zwirner, while Hauser & Wirth sold George Condo’s Untitled (Taxi Painting) (2011) for around $4 million.
Along with another of their big-ticket items, Louise Bourgeois’s Persistent Antagonism (1946-48) which sold for $3.2 million, the Condo did not even appear at the fair as they were sold before it began after VIP clients were sent a preview list.
Alex Katz's Orange Hat 2 was sold by Thaddaeus Ropac for $2.5 million, while Pace Gallery sold Heroines, Beyoncé, Serena and Althea by Sam Gilliam for $1.1 million.
Its satellite fairs, NADA and Untitled Art, also reported long lines of VIPS waiting to get in when they opened on Tuesday.